Themis to Present Phase 2 Interim Results for Chikungunya Vaccine Candidate at ASTMH 2017 Annual Meeting

Vienna, Austria, November 6, 2017 – Themis today announced positive interim results from an ongoing phase 2 clinical study designed to demonstrate safety and immunogenicity of MV-CHIK, the Company’s live attenuated prophylactic vaccine candidate for chikungunya fever. The data will be presented today for the first time at the Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH) in Baltimore, MA, USA. Final results of the trial in 320 healthy subjects currently ongoing in Austria and Germany are expected in 2018.

“The data we have generated so far in our clinical development program for chikungunya are very encouraging. All currently active phase 2 trials including a study in a previously epidemic area are progressing well and we expect final results in 2018 and 2019, respectively to further increase the value proposition of our product candidate. Overall, Themis continues to lead in the development of a vaccine against chikungunya,“ commented Dr. Erich Tauber, CEO and founder of Themis. “Above and beyond chikungunya, the trial results further validate our technology platform, which has the potential to become the leading source for innovative vaccines against several emerging and established infectious diseases.”

Themis’ unique technology platform is based on a measles vaccine vector that can be easily modified genetically in a “plug-and play” fashion to express a variety of selected antigen proteins that are present in infectious pathogens. The Company’s product portfolio based on this platform includes clinical product candidates in chikungunya and Zika with additional preclinical candidates in Respiratory Syncytial Virus (RSV), norovirus and Cytomegalovirus (CMV).

About Themis:

Themis is developing urgently needed vaccines to prevent death and disability around the world. We lead in the development of a vaccine against chikungunya, a serious debilitating disease with global outbreak potential. Our innovation in vaccine technology has created a powerful platform and a growing pipeline addressing a broad range of infectious diseases. Together with industrial and academic leaders we work to prevent illness across the globe. For more information, visit http://www.themisbio.com.

About Chikungunya

Chikungunya fever is a viral infection transmitted by specific mosquitoes. It originates in Africa but the increase in global traveling and rising temperatures cause these mosquitoes and the viruses they carry to spread into more temperate zones. Within the last four years, well over 1.7 million cases have been reported from 45 countries in the Americas and the Caribbean alone. The majority of infected persons develop severe joint pain, which can become chronic.